Lakshminarasimhan Krishnaswamy

Lecturer

Email: y_xevfuanfjnzl@fhgq.rqh.ft
Telephone: +65 6499 4737
Research Areas:
Bio-Medical Engineering

Pillar / Cluster: Engineering Product Development

Biography

Lakshminarasimhan Krishnaswamy (‘Simhan’) received his Ph.D. from Iowa State University, USA. He had studied how jumping genes (transposons) jumble the genome in Arabidopsis (a model plant), under the guidance of Dr.Thomas Peterson. He pursued his postdoctoral research at Dr.James Birchler’s lab, University of Missouri, Columbia, USA, where he explored molecular strategies to generate minichromosomes in maize.

Earlier he had obtained his BSc in Botany from The American College, Madurai, India. He joined the National Centre for Biological Sciences (NCBS), Bangalore, India, for his MSc and studied differential expression of genes in the brain of epileptic rats, in Dr.Mitradas Panicker’s lab. However he realized he wasn’t comfortable doing research using animals and decided to move back to plants for his Ph.D.

Simhan served as lecturer at Monash University (Sunway campus) for a year before he joined the biology team at SUTD. Here he enjoys teaching Introductory Biology, guiding students in their UROP research, and investigating novel pedagogical methods that enhance student learning.

Education Background

  • Postdoctoral researcher, (2007 – 2011), University of Missouri, Columbia, USA.
  • Ph.D., (2000 –  2007), Iowa State University, Ames, USA.
  • M.Sc., (1997 –  2000), National Centre for Biological Sciences, Bangalore, India.

Awards & Achievements

  • Biotechnology Fellowship by the Iowa State University, December 2000.
  • PACE award (Premium for Academic Excellence) by the Iowa State University, 2000 – 2001 & 2001 – 2002.

Key Publications

  1. Gaeta RT, Masonbrink RE, Zhao C, Sanyal A, Krishnaswamy L, Birchler JA. In vivo modification of a maize engineered minichromosome. Chromosoma. 2013 Jun;122(3):221-32. PubMed PMID: 23519820.
  2. Robert T. Gaeta, Rick E. Masonbrink, Lakshminarasimhan Krishnaswamy, Changzeng Zhao and James A. Birchler. Synthetic chromosome platforms in plants. The Annual Review of Plant Biology, 2012 Jun 2;63:307-30
  3. James A. Birchler, Lakshminarasimhan Krishnaswamy, Robert T. Gaeta, Rick E. Masonbrink, and Changzeng Zhao.Engineered Minichromosomes in Plants. Critical Reviews in Plant Sciences, 29:1–13, 2010.
  4. Krishnaswamy L, Zhang J, Peterson T. Fusion of reverse-oriented Ds termini following abortive transposition in Arabidopsis: implications for the mechanism of Ac/Ds transposition. Plant Cell Rep. 2010 Apr; 29(4):413-7.
  5. Krishnaswamy L, Zhang J, Peterson T. Reversed end Ds element: a novel tool for chromosome engineering in Arabidopsis. Plant Mol Biol. 2008; 68(4-5): 399-411.
  6. Krishnaswamy L. Transposon biology – A historical perspective. Current Science, 2007, 93, (7): 1021-1024.
  7. Krishnaswamy L and Peterson T. An Alternate Hypothesis to explain the high frequency of “revertants” in Hotheadmutants in Arabidopsis. Plant Biology 2006 Oct 17; Jan;9(1):30-1.
  8. Bhaduri A, Krishnaswamy L, Ullal GR, Panicker MM, Sowdhamini R. Fold prediction and comparative modeling of Bdm1: a probable alpha/beta hydrolase associated with hot water epilepsy. J Mol Model (Online). 2003 Feb;9(1):3-8. Epub 2003 Jan 17.

Book Chapters

  1. Lakshminarasimhan Krishnaswamy and Thomas Peterson. Survey of Natural and Transgenic Gene Markers Used to Monitor Transposon Activity: Methods and Protocols’, 2013; 1057:43-58, Humana Press, DOI 10.1007/978-1-62703-568-2_4.
  2. Gaeta R. T., Krishnaswamy L. Engineered Plant Minichromosomes in ‘Plant Chromosome Engineering: Methods and Protocols’, 2011; V701:131-46, Humana Press, ISBN: 978-1-61737-956-7.
  3. Jianbo Zhang, Chuanhe Yu, Lakshminarasimhan Krishnaswamy, and Thomas Peterson. Transposable elements as catalysts for chromosome rearrangements in ‘Plant Chromosome Engineering: Methods and Protocols’, 2011; V.701: 315 – 326; Humana Press, ISBN: 978-1-61737-956-7.

Service Commitments to EPD

  • SUTD IRB committee
  • SUTD Communication Intensive Course committee
  • SUTD UROP committee
  • EPD Pedagogy committee